Yamaha took control of the timesheets in the early stages of FP2, with Valentino Rossi on the factory team bike with a 1m33.128s.
FP1 pacesetter Fabio Quartararo guided his Petronas M1 to a 1m32.672s to demote Rossi, though this was soon usurped by Miguel Oliveira on the Tech 3 KTM.
The Portuguese rider’s 1m32.603s came just as factory KTM counterpart Pol Espargaro crashed at Turn 13.
Quartararo then began a run of session-best laps, beginning with a 1m32.449s and culminating in a 1m32.273s three tours later.
This stood as the benchmark for the next 15 minutes, before Francesco Bagnaia on the Pramac Ducati edged ahead with a 1m32.138s.
As the field switched to fresh soft rubber in the final seven minutes for a time attack, Espargaro brushed off his earlier tumble to lower the benchmark to a 1m32.023s.
He improved this to a 1m31.699s on the following tour, though he was immediately beaten by Takaaki Nakagami on the year-old LCR Honda with a 1m31.630s.
Honda is a depleted force in the second Misano round, with works rider Stefan Bradl forced to pull out owing to issues with his arm in FP1, leaving just Nakagami and Alex Marquez as HRC’s only representatives this weekend.
With just under three minutes to run, Brno race winner Binder went 0.002s quicker than Nakagami to end the day fastest of…